{"id":396,"date":"2024-05-13T00:45:21","date_gmt":"2024-05-12T22:45:21","guid":{"rendered":"https:\/\/sfsb.farm.unipi.it\/?page_id=396"},"modified":"2024-05-15T23:21:12","modified_gmt":"2024-05-15T21:21:12","slug":"sardelli-francesca","status":"publish","type":"page","link":"https:\/\/sfsb.farm.unipi.it\/en\/cicli-attivi\/sardelli-francesca\/","title":{"rendered":"Sardelli Francesca"},"content":{"rendered":"
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Contacts<\/strong>: <\/p>\n\n\n\n

francesca.sardelli@phd.unipi.it<\/a><\/p>\n\n\n\n

Supervisor(s)<\/strong>:<\/p>\n\n\n\n

Professor Mauro Pineschi and Simona Rapposelli<\/p>\n\n\n\n

PhD project Title<\/strong>:<\/p>\n\n\n\n

Development of new small molecules having GLP-1 secretagogue activity leveraging on new mechanism of action<\/p>\n\n\n\n

Abstract of the PhD project<\/strong>:<\/p>\n\n\n\n

This research project is focussed on the rational preparation of a library of new small molecules based on a 1,3-diaza-4-oxa-[3.3.1] bicyclic scaffold as potential candidates for the treatment of diabesity (diabetes and obesity) and neurodegenerative diseases, such as Alzheimer\u2019s and Parkinson\u2019s diseases. In fact, these new compounds have shown GLP-1 (Glucagon-Like Peptide-1) secretagogue activity, both in vitro and in vivo. GLP-1 is an incretin hormone which leads to numerous metabolic effects, including glucose-dependent stimulation of insulin secretion. Moreover, a failure of GLP-1 receptors has shown evident damages in several neurological activities. Currently, many GLP-1 mimetic peptides are commercially available. Anyway, they present many problems in terms of stability and administration. Hence, the aim of this project is to obtain a new non-peptide and orally active drug for the treatment of diabetes and neurodegenerative disorders.<\/p>\n\n\n\n

Publications link: <\/strong><\/p>\n\n\n\n

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Contacts: francesca.sardelli@phd.unipi.it Supervisor(s): Professor Mauro Pineschi and Simona Rapposelli PhD project Title: Development of new small molecules having GLP-1 secretagogue activity leveraging on new mechanism of action Abstract of the PhD project: This research project is focussed on the rational preparation of a library of new small molecules based on…<\/p>\n

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