{"id":196,"date":"2024-04-10T00:16:36","date_gmt":"2024-04-09T22:16:36","guid":{"rendered":"https:\/\/sfsb.farm.unipi.it\/?page_id=196"},"modified":"2026-03-04T13:38:05","modified_gmt":"2026-03-04T12:38:05","slug":"comparini-lucrezia-margherita","status":"publish","type":"page","link":"https:\/\/sfsb.farm.unipi.it\/en\/cicli-conclusi\/comparini-lucrezia-margherita\/","title":{"rendered":"Comparini Lucrezia Margherita"},"content":{"rendered":"<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"200\" height=\"230\" src=\"https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Comparini.jpeg\" alt=\"\" class=\"wp-image-197\" srcset=\"https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Comparini.jpeg 200w, https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Comparini-10x12.jpeg 10w, https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Comparini-130x150.jpeg 130w\" sizes=\"auto, (max-width: 200px) 100vw, 200px\" \/><\/figure>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Contacts<\/strong>: <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><a href=\"mailto:salvatore.galati@phd.unipi.it\">lucrezia.comparini<em>@<\/em>phd.unipi.it<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Supervisor(s)<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Professor Mauro Pineschi<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>PhD project Title<\/strong>:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Development of new small molecules targeting GLP-1 secretion<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Abstract of the PhD project<\/strong>:<\/p>\n\n\n\n<p class=\"has-text-align-left justify-text wp-block-paragraph\">GLP-1 is an incretin hormone released by intestinal L-cells mostly after food ingestion. Binding its receptor, GLP-1 enhances the secretion of insulin from pancreatic <em>b<\/em>-cells, reduces gastric emptying and food intake. This makes GLP-1 receptor an interesting target for diabetes treatment, moreover, GLP-1 agonists have been proven to be neuroprotective and neuro-regenerative agents. GLP-1 mimetic peptides are commercially available, but they present problems such as low stability and compliance, and various side effects. 1,3-diaza-4-oxa-[3,3,1]bicyclic scaffolds obtained in our lab with a four-step linear synthesis, being small molecules with the right physicochemical feature for an oral administration, are effective candidates to enhance GLP-1 secretion both <em>in vitro<\/em> and <em>in vivo<\/em>. The aim of this research project is the construction of a library of compounds having this scaffold, the evaluation of their antidiabetic and neuroprotective activity, and the study of the mechanism of action.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Publications link: <\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><a href=\"https:\/\/www.scopus.com\/authid\/detail.uri?authorId=57372527400\" target=\"_blank\" rel=\"noreferrer noopener\"><img loading=\"lazy\" decoding=\"async\" width=\"120\" height=\"36\" src=\"https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Scopus-2.png\" alt=\"\" class=\"wp-image-184\" style=\"width:auto;height:20px\" srcset=\"https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Scopus-2.png 120w, https:\/\/sfsb.farm.unipi.it\/wp-content\/uploads\/2024\/04\/Scopus-2-18x5.png 18w\" sizes=\"auto, (max-width: 120px) 100vw, 120px\" \/><\/a><\/figure>\n\n\n\n<div style=\"height:10px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Oral communications at conferences:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>&#8220;Development of antidiabetic small molecules acting as GLP-1 secretagogues&#8221; MYCS: Merk young chemist\u2019 symposium, Rimini (Italy); 22-24\/11\/2021.<\/li>\n\n\n\n<li>&#8220;Chemical manipulation of biologically active heterobicycles&#8221; SCI- VISYOChem 2022, online, 24-27\/10\/2022.<\/li>\n\n\n\n<li>&#8220;Harnessing heterobicyclic reactivity to access chemical diversity&#8221; CINMPIS days, Pisa (Italy); 09-11\/02\/2023.<\/li>\n\n\n\n<li>&#8220;Development of ring-opening reactions of cyclic gem-diamines with Grignard reagents&#8221; &#8220;Attilio Corbella&#8221; International Summer School on Organic Synthesis (ISOS2023), Gargnano Italy); 18-22\/06\/2023.<\/li>\n\n\n\n<li>\u201cAsymmetric synthesis of (-)-Quinagolide via enzymatic resolution and stereoselective iminium ion reduction\u201d XLI Convegno Nazionale della Divisione di Chimica Organica della Societ\u00e0 Chimica Italiana, Roma (Italy); 10-14\/09\/2023.<\/li>\n<\/ul>","protected":false},"excerpt":{"rendered":"<p>Contacts: lucrezia.comparini@phd.unipi.it Supervisor(s): Professor Mauro Pineschi PhD project Title: Development of new small molecules targeting GLP-1 secretion Abstract of the PhD project: GLP-1 is an incretin hormone released by intestinal L-cells mostly after food ingestion. Binding its receptor, GLP-1 enhances the secretion of insulin from pancreatic b-cells, reduces gastric emptying&#8230;<\/p>\n<p class=\"continue-reading-button\"> <a class=\"continue-reading-link\" href=\"https:\/\/sfsb.farm.unipi.it\/en\/cicli-conclusi\/comparini-lucrezia-margherita\/\">Continue reading<i class=\"crycon-right-dir\"><\/i><\/a><\/p>","protected":false},"author":1,"featured_media":0,"parent":615,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-196","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/pages\/196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/comments?post=196"}],"version-history":[{"count":3,"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/pages\/196\/revisions"}],"predecessor-version":[{"id":311,"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/pages\/196\/revisions\/311"}],"up":[{"embeddable":true,"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/pages\/615"}],"wp:attachment":[{"href":"https:\/\/sfsb.farm.unipi.it\/en\/wp-json\/wp\/v2\/media?parent=196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}