Contacts:
Supervisor(s):
Professor Monti and Prof Tampucci
PhD project Title:
Design and Development of Innovative and Environmentally Sustainable Aesthetic Products for Therapeutic Applications
Abstract of the PhD project:
The project investigates innovative and sustainable biomaterials for cutaneous tissue regeneration and aesthetic applications with therapeutic relevance. Marine-derived sources, such as fish processing by-products, will be explored as alternative reservoirs of glycosaminoglycans for regenerative medicine. Extraction methods for collagen, hyaluronic acid, and proteoglycans will be developed with a focus on sustainability and applicability in scaffold fabrication. Advanced delivery systems for bioactive molecules—such as self-assembling polymeric nanomicelles and polymeric nanoparticles, optionally coated with hyaluronic acid—will be designed to enhance dermal targeting, bioavailability, and minimize adverse effects. Physicochemical characterization will assess parameters influencing skin retention and enzymatic responsiveness. The process will be scaled up under GMP-compliant cleanroom conditions for intradermal use. Biopharmaceutical evaluation will be performed through ex vivo and in vivo models, following the ethical principles of the 3Rs.
Publications link:
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IT_IT