Contacts:
Supervisor(s):
Professor Clementina Manera and Simona Rapposelli
PhD project Title:
Synthesis and biological evaluation by SCAR laser spectroscopy of cell metabolism modulators
Abstract of the PhD project:
The glucose-6-phosphate dehydrogenase (G6PD) is the rate limiting enzyme of the pentose phosphate pathway, which produces ribulose and reduced nicotinamide adenine dinucleotide phosphate (NADPH) starting from glucose. G6PD is often upregulated in tumors since it’s used by cancer cells to counteract oxidative stress and support the synthesis of nucleic acids. The aim of the present research project is to synthesize some G6PD modulators and to evaluate their activity by 14C-radiolabeling of G6PD substrate. We intend to accomplish the latter purpose by using Saturated-absorption Cavity Ring-down (SCAR) laser spectroscopy, a new analytical technology for the determination of 14C.
Publications link:
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